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557324 Riluzole - CAS 1744-22-5 - Calbiochem

A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.

Riluzole - CAS 1744-22-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124

Primary Target: Inhibits glutamate release and blocks Na+ channels
557324
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
1744-22-5C₈H₅F₃N₂OS

Products

KatalógusszámCsomagolás Menny./csomag
557324-50MG Alumíniumdob 50 mg
Description
OverviewA cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Shown to function as a polyglutamine aggregation inhibitor and stimulates the synthesis of NGF, BDNF, and GDNF in mouse astrocyte cultures. Reported to offer neuroprotection, slow down disease progression in ALS (amyotrophic lateral sclerosis) patients, and prolong the lifespan of animal models of HD (Huntington’s disease).
Catalogue Number557324
Brand Family Calbiochem®
Synonyms2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
References
ReferencesHeiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 16400.
Schiefer, J., et al. 2002. Mov. Disord. 17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett. 310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci. 18, 196.
Mizoule, J., et al. 1985. Neuropharmacology 24, 767.
Product Information
CAS number1744-22-5
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₈H₅F₃N₂OS
Chemical formulaC₈H₅F₃N₂OS
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibits glutamate release and blocks Na+ channels
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
ContaminantsHeavy metals: ≤20 ppm
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDL2830000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
557324-50MG 04055977267938

Documentation

Riluzole - CAS 1744-22-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Riluzole - CAS 1744-22-5 - Calbiochem Certificates of Analysis

TitleLot Number
557324

References

Hivatkozások áttekintése
Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 16400.
Schiefer, J., et al. 2002. Mov. Disord. 17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett. 310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci. 18, 196.
Mizoule, J., et al. 1985. Neuropharmacology 24, 767.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
Synonyms2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
DescriptionA cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington's disease (HD).
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1744-22-5
RTECSDL2830000
Chemical formulaC₈H₅F₃N₂OS
Purity≥97% by HPLC
ContaminantsHeavy metals: ≤20 ppm
SolubilityDMSO (40 mg/ml) or HCl (0.1N)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
Merck USA index14, 8223
ReferencesHeiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 16400.
Schiefer, J., et al. 2002. Mov. Disord. 17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett. 310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci. 18, 196.
Mizoule, J., et al. 1985. Neuropharmacology 24, 767.