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557354 ROS Inhibitor, YCG063 - CAS 330997-95-0 - Calbiochem

The ROS Inhibitor, YCG063, also referenced under CAS 330997-95-0, controls the biological activity of ROS.

ROS Inhibitor, YCG063 - CAS 330997-95-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: YCG063 ROS Inhibitor

557354
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
330997-95-0C₁₉H₂₅N₅O₄S
Description
OverviewA cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤ 10 µM) in HepG2 and other cells, and suppresses cellular growth (≤ 50 µM) in HUVEC, HeLa, and HCT15 cultures. At ≤ 10 µM, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECs in vitro without obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhage in vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 µM). dose-dependently.
Catalogue Number557354
Brand Family Calbiochem®
SynonymsYCG063 ROS Inhibitor
References
ReferencesKim, K.H., et al. 2011. Biochem. Biophys. Res. Commun. 404, 541.
Product Information
CAS number330997-95-0
FormWhite solid
Hill FormulaC₁₉H₂₅N₅O₄S
Chemical formulaC₁₉H₂₅N₅O₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
557354 0

Documentation

ROS Inhibitor, YCG063 - CAS 330997-95-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

ROS Inhibitor, YCG063 - CAS 330997-95-0 - Calbiochem Certificates of Analysis

TitleLot Number
557354

References

Hivatkozások áttekintése
Kim, K.H., et al. 2011. Biochem. Biophys. Res. Commun. 404, 541.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-August-2011 RFH
SynonymsYCG063 ROS Inhibitor
DescriptionA cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤10 µM) in HepG2 and other cells, and suppresses cellular growth (≤50 µM) in HUVEC, HeLa, and HCT15 cultures. At ≤10 µM, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECs in vitro without obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhage in vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 µM) dose-dependently.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number330997-95-0
Chemical formulaC₁₉H₂₅N₅O₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKim, K.H., et al. 2011. Biochem. Biophys. Res. Commun. 404, 541.