Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

539164 Proteasome Inhibitor Set I - Calbiochem

Proteasome Inhibitor Set I contains 1 mg of Proteasome Inhibitor I (Cat. No. 539160), 200 µg of Lactacystin (Cat. No. 426100), and 1 mg of MG-132 (Cat. No. 474790). Supplied with a data sheet.

Proteasome Inhibitor Set I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: MPC
539164
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Products

KatalógusszámCsomagolás Menny./csomag
539164-1SET Üvegpalack 1 set
Description
OverviewContains 1 mg of Proteasome Inhibitor I (Cat. No. 539160), 200 µg of Lactacystin (Cat. No. 426100), and 1 mg of MG-132 (Cat. No. 474790). Supplied with a data sheet.
Catalogue Number539164
Brand Family Calbiochem®
References
ReferencesGrimm, L.M., et al. 1996. EMBO J. 15, 3835.
Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
Fenteany, G., et al. 1995. Science 268, 726.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.
Product Information
FormSolid
Quality LevelMQ100
Applications
ApplicationProteasome Inhibitor Set I contains 1 mg of Proteasome Inhibitor I (Cat. No. 539160), 200 µg of Lactacystin (Cat. No. 426100), and 1 mg of MG-132 (Cat. No. 474790). Supplied with a data sheet.
Biological Information
Primary TargetMPC
Secondary targetNF-κB activity
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
539164-1SET 04055977269482

Documentation

Proteasome Inhibitor Set I - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Proteasome Inhibitor Set I - Calbiochem Certificates of Analysis

TitleLot Number
539164

References

Hivatkozások áttekintése
Grimm, L.M., et al. 1996. EMBO J. 15, 3835.
Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
Fenteany, G., et al. 1995. Science 268, 726.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Proteasomes Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-September-2008 RFH
DescriptionProteasomes are large multi-subunit protease complexes, localized in the nucleus and cytosol, which selectively degrade intracellular proteins. They play a major role in the degradation of many proteins involved in cell cycling, proliferation, and apoptosis. A vast majority of short-lived proteins are degraded by the ubiquitin-proteasome pathway. A protein marked for degradation is covalently attached to multiple molecules of ubiquitin (Ubq), a highly conserved 76-amino acid (8.6 kDa) protein, which escorts it for rapid hydrolysis to the multi-component enzymatic complex known as the 26S proteasome. The proteolytic core of this complex, the 20S proteasome, contains multiple peptidase activities and functions as the catalytic machine.

The ubiquitin-proteasome pathway plays a major role in the breakdown of abnormal proteins that result from oxidative stress and mutations that might otherwise disrupt normal cellular homeostasis. The reactive oxygen species can promote partial unfolding of the proteins, exposing its hydrophobic domains to proteolytic enzymes of the 20S complex. Rapid degradation of defective enzymes, as seen in diseases caused by metabolic abnormalities, also occurs in the proteasome. The Ubq-proteasome pathway has also been implicated in several forms of malignancy, in the pathogenesis of several genetic diseases, and in the pathology of muscle wasting. It is also involved in the destruction of proteins that participate in cell cycle progression, transcription control, signal transduction, and metabolic regulation.
FormSolid
Storage -20°C
Do Not Freeze Ok to freeze
Toxicity Standard Handling
ReferencesGrimm, L.M., et al. 1996. EMBO J. 15, 3835.
Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
Fenteany, G., et al. 1995. Science 268, 726.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.