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370653 PknG Inhibitor - CAS 329221-38-7 - Calbiochem

The PknG Inhibitor, also referenced under CAS 329221-38-7, controls the biological activity of PknG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PknG Inhibitor - CAS 329221-38-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017

370653
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
329221-38-7C₁₃H₁₆N₂O₂S

Products

KatalógusszámCsomagolás Menny./csomag
370653-10MG Muanyagampulla 10 mg
Description
OverviewA cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.
Catalogue Number370653
Brand Family Calbiochem®
SynonymsMycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017
References
ReferencesScherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
Walburger, A., et al. 2004. Science 304, 1800.
Product Information
CAS number329221-38-7
FormLight brown solid
Hill FormulaC₁₃H₁₆N₂O₂S
Chemical formulaC₁₃H₁₆N₂O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
370653-10MG 04055977191639

Documentation

PknG Inhibitor - CAS 329221-38-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PknG Inhibitor - CAS 329221-38-7 - Calbiochem Certificates of Analysis

TitleLot Number
370653

References

Hivatkozások áttekintése
Scherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
Walburger, A., et al. 2004. Science 304, 1800.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsMycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017
DescriptionA cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.
FormLight brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number329221-38-7
Chemical formulaC₁₃H₁₆N₂O₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesScherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
Walburger, A., et al. 2004. Science 304, 1800.