516481 Sigma-AldrichPepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem
Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.
More>> Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Less<<Synonyms: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
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Áttekintés
Replacement Information |
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Kulcsspecifikációk táblázata
CAS # | Empirical Formula |
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26305-03-3 | C₃₄H₆₃N₅O₉ |
Products
Katalógusszám | Csomagolás | Menny./csomag | |
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516481-100MG | Muanyagampulla | 100 mg | |
516481-25MG | Muanyagampulla | 25 mg | |
516481-5MG | Muanyagampulla | 5 mg |
Description | |
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Overview | A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437). |
Effective concentration: 1.0 µM. | |
Catalogue Number | 516481 |
Brand Family | Calbiochem® |
Synonyms | Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid |
Product Information | |
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CAS number | 26305-03-3 |
ATP Competitive | N |
Form | White solid |
Hill Formula | C₃₄H₆₃N₅O₉ |
Chemical formula | C₃₄H₆₃N₅O₉ |
Optical rotation | Optical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C). |
Reversible | Y |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | cathepsin D |
Primary Target IC<sub>50</sub> | EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | N |
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Toxicological Information |
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Safety Information according to GHS | |
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RTECS | SC6155000 |
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Specifications |
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Global Trade Item Number | |
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Katalógusszám | GTIN |
516481-100MG | 04055977198812 |
516481-25MG | 07790788055837 |
516481-5MG | 04055977198836 |
Documentation
Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem MSDS
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Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Certificates of Analysis
Title | Lot Number |
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516481 |
References
Hivatkozások áttekintése |
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Isahara, K., et al. 1999. Neuroscience 91, 233. Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204. Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233. Carraway, R.E., et al. 1991. Peptides 12, 107. Eid, M., et al. 1981. Biochem. J. 197, 465. Umezawa, H., et al. 1970. J. Antibiot. 23, 259. |
Brochure
Title |
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Western Blotting Tools |
Technical Info
Title |
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Protein Blotting Handbook: 6th Edition |