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540215 PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem

The PTP CD45 Inhibitor, also referenced under CAS 345630-40-2, controls the biological activity of PTP CD45. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

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PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V

Primary Target: CD45 using pNPP as a substrate
540215
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
345630-40-2C₁₉H₁₇NO₃

Products

KatalógusszámCsomagolás Menny./csomag
540215-5MG Muanyagampulla 5 mg
Hozzáadás a Kedvencekhez
Description
OverviewA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 µM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). Does not effectively inhibit PTPIB (IC50 >30 µM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
Catalogue Number540215
Brand Family Calbiochem®
SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V
References
ReferencesLi, Y., et al. 2011. Blood 117, 6702.
Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
Product Information
CAS number345630-40-2
ATP CompetitiveN
FormRed-violet solid
Hill FormulaC₁₉H₁₇NO₃
Chemical formulaC₁₉H₁₇NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCD45 using pNPP as a substrate
Primary Target IC<sub>50</sub>200 nM or 3.8 µM against CD45 using pNPP or phosphorylated Ick505 peptide as a substrate, respectively
Purity≥ 97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
540215-5MG 07790788051372