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506074 PP2A Activating Ligand, ITH12246 - CAS 1228658-31-8 - Calbiochem

PP2A Activating Ligand, ITH12246 - CAS 1228658-31-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PP2A
506074
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
1228658-31-8C₁₆H₁₉N₃O₂·HCl

Products

KatalógusszámCsomagolás Menny./csomag
5.06074.0001 Üvegpalack 10 mg
Hozzáadás a Kedvencekhez
Description
OverviewA cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against β-amyloid peptides (Ab1-42) toxicity and okadaic acid (Cat. No. 459620)-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300 nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~ 3.0 µM). Shown to reverse the scopolamine-induced memory loss in mice (~10 mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5 mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60 nM) and human erythrocytes (IC50 = 780 nM).
Catalogue Number506074
Brand Family Calbiochem®
References
ReferencesLorrio, S., et al. 2013. ACS Chem. Neurosci. 4,1267.
de Los Rios, C., et al. 2010. J. Med. Chem. 53,5129.
Product Information
CAS number1228658-31-8
FormOff-white powder
Hill FormulaC₁₆H₁₉N₃O₂·HCl
Chemical formulaC₁₆H₁₉N₃O₂·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPP2A
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
5.06074.0001 04055977243079