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539652 PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem

The PKCβII/EGFR Inhibitor, also referenced under CAS 145915-60-2, controls the biological activity of PKCβII/EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphory

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PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide, CGP 53 353

Primary Target: EGFR
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
145915-60-2C₂₀H₁₃F₂N₃O₂
Description
OverviewA cell-permeable symmetrical phthalimide compound that acts as a potent, reversible, and ATP-competitive inhibitor of EGFR and PKC isozymes α, βI, and βII (IC50 = 0.7 µM, 1.9 µM, 3.8 µM, and 0.41 µM, respectively). Only weakly inhibits the activity of a panel of 16 other kinases, including novel and atypical PKC isozymes. Reported to inhibit insulin-stimulated cellular 2-deoxyglucose uptake, osteoclast differentiation, ERK activation, and TLS/FUS DNA-binding activity in vitro. Also reported to exhibit antitumor activity in mice in vivo.
Catalogue Number539652
Brand Family Calbiochem®
SynonymsCG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide, CGP 53 353
References
ReferencesKouroedov, A., et al. 2004. Circulation 110, 91.
Lee, S.W., et al. 2003. Bone 32, 217.
Perrotti, D., et al. 1998. EMBO J. 17, 4442.
Chalfant, C.E., et al. 1996. Mol. Endocrinol. 10, 1273.
Buchdunger, E., et al. 1995. Clin. Cancer Res. 1, 813.
Trinks, U., et al. 1994. J. Med. Chem. 37, 1015.
Product Information
CAS number145915-60-2
ATP CompetitiveY
FormOrange solid
Hill FormulaC₂₀H₁₃F₂N₃O₂
Chemical formulaC₂₀H₁₃F₂N₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>0.7 µM, 1.9 µM, 3.8 µM, and 0.41 µM against EGFR and PKC isozymes α, βI, and βII, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
539652 0