Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

539654 PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem

The PKCβ Inhibitor, also referenced under CAS 257879-35-9, controls the biological activity of PKCβ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione

Primary Target: PKCβII, βI
539654
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
257879-35-9C₂₄H₂₁N₅O₂
Description
Overview

This product has been discontinued.



An anilino-monoindolylmaleimide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI) and displays greater selectivity over PKCα, γ,& ε (IC50 = 331 nM, > 1 µM, and 2.8 µM, respectively).
Catalogue Number539654
Brand Family Calbiochem®
Synonyms3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
References
ReferencesTanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.
Product Information
CAS number257879-35-9
ATP CompetitiveY
FormOrange solid
Hill FormulaC₂₄H₂₁N₅O₂
Chemical formulaC₂₄H₂₁N₅O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKCβII, βI
Primary Target IC<sub>50</sub>5 nM, 21 nM for human PKCβII and βI
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
539654 0

Documentation

PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem Certificates of Analysis

TitleLot Number
539654

References

Hivatkozások áttekintése
Tanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2010 RFH
Synonyms3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
DescriptionA potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI, respectively). Displays greater selectivity for PKCβ compared to PKCα, PKCγ,and PKCε (IC50 = 331 nM, >1 µM, and 2.8 µM, respectively).
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number257879-35-9
Chemical formulaC₂₄H₂₁N₅O₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.