Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

528819 PARP Inhibitor XI, DR2313

The PARP Inhibitor XI, DR2313, also referenced under CAS 284028-90-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

PARP Inhibitor XI, DR2313 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one

Primary Target: PARP
528819
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
284028-90-6C₈H₁₀N₂OS
Description
Overview

This product has been discontinued.





A brain-permeable and water soluble pyrimidinone compound that acts as a potent and NAD+-competitive inhibitor of PARP (IC50 = 200 nM and 240 nM for rhPARP1 and rmPARP2, respectively) with little activity against the dehydrogenase activity of GAPDH, ADH, LDH, or the ADP-ribosylase activity of bacterial diphtheria toxin even at concentrations as high as 10 µM. Shown to inhibit H2O2-induced PAR formation and neuronal cell death in primary rat cerebral cortex culture in vitro (EC50 = 270 nM) and exhibit neuroprotective effects in both permanent and transient focal ischemia models in rat in in vivo.
Catalogue Number528819
Brand Family Calbiochem®
Synonyms2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one
References
ReferencesNakajima, H., et al. 2005. J. Pharmacol. Exp. Ther. 312, 472.
Product Information
CAS number284028-90-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₀N₂OS
Chemical formulaC₈H₁₀N₂OS
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPARP
Primary Target IC<sub>50</sub>200 nM and 240 nM for rhPARP1 and rmPARP2, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
528819 0

Documentation

PARP Inhibitor XI, DR2313 MSDS

Title

Safety Data Sheet (SDS) 

PARP Inhibitor XI, DR2313 Certificates of Analysis

TitleLot Number
528819

References

Hivatkozások áttekintése
Nakajima, H., et al. 2005. J. Pharmacol. Exp. Ther. 312, 472.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-August-2008 RFH
Synonyms2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one
DescriptionA brain-permeable and water soluble pyrimidinone compound that acts as a potent and NAD+-competitive inhibitor of PARP (IC50 = 200 nM and 240 nM for rhPARP1 and rmPARP2, respectively) with little activity against the dehydrogenase activity of GAPDH, ADH, LDH, or the ADP-ribosylase activity of bacterial diphtheria toxin even at concentrations as high as 10 µM. Shown to inhibit H2O2-induced PAR formation and neuronal cell death in primary rat cerebral cortex culture in vitro (EC50 = 270 nM) and exhibit neuroprotective effects in both permanent and transient focal ischemia models in rat in in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number284028-90-6
Chemical formulaC₈H₁₀N₂OS
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (30 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesNakajima, H., et al. 2005. J. Pharmacol. Exp. Ther. 312, 472.