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497985 Ornithine Decarboxylase Inhibitor, POB - Calbiochem

497985
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₁₉H₃₁N₃O₆

Products

KatalógusszámCsomagolás Menny./csomag
497985-10MG Üvegpalack 10 mg
Description
OverviewA cell-permeable pyridoxyl-ornithine compound that acts as an effective analog of the transition state coenzyme-substrate adduct during orthithine decarboxylase- (ODC) catalyzed conversion of L-orthithine to Pultrescine. POB is typically 5- to 10-fold more potent than DFMO (Cat. No. 288500) in inhibiting intracellular ODC activity and tumor cell growth in cultures, while exhibiting little effect against the growth of nontumorigenic human aortic smooth muscle cells.
Catalogue Number497985
Brand Family Calbiochem®
SynonymsN-(4ʹ-Pyridoxyl)-Ornithine(BOC)-OMe, ODC Inhibitor, POB
References
ReferencesWu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.
Product Information
FormWhite to off-white solid
FormulationSupplied as a hydrochloride salt.
Hill FormulaC₁₉H₃₁N₃O₆
Chemical formulaC₁₉H₃₁N₃O₆
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
497985-10MG 04055977199888

Documentation

Ornithine Decarboxylase Inhibitor, POB - Calbiochem Certificates of Analysis

TitleLot Number
497985

References

Hivatkozások áttekintése
Wu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2018 JSW
SynonymsN-(4ʹ-Pyridoxyl)-Ornithine(BOC)-OMe, ODC Inhibitor, POB
DescriptionA cell-permeable pyridoxyl-ornithine compound that acts as an effective analog of the transition state coenzyme-substrate adduct during orthithine decarboxylase- (ODC) catalyzed conversion of L-orthithine to Pultrescine. POB is typically 5- to 10-fold more potent than DFMO (Cat. No. 288500) in inhibiting intracellular ODC activity and tumor cell growth in cultures, while exhibiting little effect against the growth of nontumorigenic human aortic smooth muscle cells.
FormWhite to off-white solid
FormulationSupplied as a hydrochloride salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₉H₃₁N₃O₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWu, F., et al. 2007. Mol. Cancer Ther. 6, 1831.