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CBL212-KC Neurofilament 200 MS x HU (KC) MG

Anti-Neurofilament 200 kDa Antibody, clone RT97 detects level of Neurofilament 200 kDa & has been published & validated for use in IH, IH(P).

Neurofilament 200 MS x HU (KC) MG MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CBL212-KC
Bulk packaging. Please inquire.  
Purchase on Sigma-Aldrich

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Description
Catalogue NumberCBL212-KC
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionNeurofilament 200 MS x HU (KC) MG
OverviewThis product is intended for use by IVD manufacturers.
Contact customer service for assistance: oem.reagents@emdmillipore.com
Alternate Names
  • Anti -Neurofilament 200
References
Product Information
FormatPurified
PresentationThe monoclonal is presented in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Quality LevelMQ300
Applications
ApplicationAnti-Neurofilament 200 kDa Antibody, clone RT97 detects level of Neurofilament 200 kDa & has been published & validated for use in IH, IH(P).
Key Applications
  • Immunohistochemistry
  • Immunohistochemistry (Paraffin)
Application NotesStaining of both frozen and paraffin wax embedded tissue sections

Strong staining of neuronal processes in a variety of tissues

Optimal working dilutions must be determined by the end user.
Biological Information
CloneRT97
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThe clone RT97 recognizes the 200 kDa neurofilament polypeptide in a number of mammalian and avian species. Tumours specifically recognized include phaeochromocytoma, paraganglioma, ganglioneuroblastoma and other tumours of neuronal origin.

KNOWN SPECIES CROSS REACTIVITY: Recognizes rat, chicken, pig and reptile
IsotypeIgG1
Species Reactivity
  • Avian
  • Chicken
  • Human
  • Mammals
  • Pig
  • Rat
  • Reptile
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • NEFH
  • NF-H
  • NFH
  • KIAA0845
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P12036 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
SIZE: 1026 amino acids; 112480 Da
PTM: There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
DISEASE: SwissProt: P12036 # Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
SIMILARITY: SwissProt: P12036 ## Belongs to the intermediate filament family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year.
Packaging Information
Material SizeBulk packaging. Please inquire.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
CBL212-KC 04053252682056

Kapcsolódó termékek és alkalmazások

Alternative Packsize

Katalógusszám Leírás
CBL212 Anti-Neurofilament 200 kDa Antibody, clone RT97

Kapcsolódó termékek gyártója: Brand Facete

Calbiochem®
Upstate®

Kategóriák

Life Science Research > Antibodies and Assays > Primary Antibodies
IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Secondary Bulk Antibodies > Anti-Human Antibodies & Conjugates > Mouse Anti-Human
IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Tumor Markers & Antigens
IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Neurological Proteins