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508148 Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem

Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone

Primary Target: 5-HT2A
508148
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
82752-99-6C₂₅H₃₂ClN₅O2·HCl

Products

KatalógusszámCsomagolás Menny./csomag
5.08148.0001 Üvegpalack 10 mg
Description
OverviewA potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
Catalogue Number508148
Brand Family Calbiochem®
Synonyms5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
References
ReferencesKim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
Cusack, B. et al. 1994. Psychopharmacol. 114, 559.
Product Information
CAS number82752-99-6
FormWhite solid
Hill FormulaC₂₅H₃₂ClN₅O2·HCl
Chemical formulaC₂₅H₃₂ClN₅O2·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT2A
Primary Target K<sub>i</sub>26nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
5.08148.0001 04055977242867

Documentation

Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
Kim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
Cusack, B. et al. 1994. Psychopharmacol. 114, 559.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2013 JSW
Synonyms5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
DescriptionA potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
FormWhite solid
CAS number82752-99-6
Chemical formulaC₂₅H₃₂ClN₅O2·HCl
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (25 mM) or Ethanol (10 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
Cusack, B. et al. 1994. Psychopharmacol. 114, 559.