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567500 Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem

Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor

Primary Target: Inhibits NHE-1-meidated pH recovery after acidosis
567500
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
861218-38-4C₁₁H₈N₄OS • CH₃SO₃H
Description
Overview

This product has been discontinued.



A cell-permeable acylguanidine compound that inhibits NHE-1-meidated pH recovery after acidosis in PS120 cells (IC50 = 2.0 µM). Shown exhibit cardioprotective efficacy both in an isolated rat heart ischemia model in vitro and in a rat myocardial infarction model in vivo.
Catalogue Number567500
Brand Family Calbiochem®
Synonyms(4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor
References
ReferencesLee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.
Product Information
CAS number861218-38-4
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₁H₈N₄OS • CH₃SO₃H
Chemical formulaC₁₁H₈N₄OS • CH₃SO₃H
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibits NHE-1-meidated pH recovery after acidosis
Primary Target IC<sub>50</sub>2.0 µM against NHE-1
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
567500 0

Documentation

Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem Certificates of Analysis

TitleLot Number
567500

References

Hivatkozások áttekintése
Lee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms(4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor
DescriptionA cell-permeable acylguanidine compound that inhibits NHE-1-meidated pH recovery after acidosis in PS120 cells (IC50 = 2.0 µM). Shown exhibit cardioprotective efficacy both in an isolated rat heart ischemia model in vitro and in a rat myocardial infarction model in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number861218-38-4
Chemical formulaC₁₁H₈N₄OS • CH₃SO₃H
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Toxicity Harmful
ReferencesLee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.