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492035 NSC 721648 - CAS 872726-44-8 - Calbiochem

NSC 721648 - CAS 872726-44-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610

492035
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
872726-44-8C₁₅H₁₂FNO₂S
Description
Overview

This product has been discontinued.



A cell-permeable benzothiazole compound that exhibits potent in vitro antiproliferative activity against HCC 2998, IGROV1, MCF-7, MDA 468, SR, and T-47D (GI50 <1 nM), while showing much reduced effect against 50 other human tumor cells in a panel screening. Although it is a high affinity AhR ligand (IC50 = 25 nM; Ki = 6.8 nM in a TCDD competitive binding study) and a known CYP1A1 inducer, neither property can fully account for its antitumor activity.
Catalogue Number492035
Brand Family Calbiochem®
Synonyms5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610
References
ReferencesAiello, S., et al. 2008. J. Med. Chem. 51, 5135.
Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.
Product Information
CAS number872726-44-8
FormWhite crystalline solid
Hill FormulaC₁₅H₁₂FNO₂S
Chemical formulaC₁₅H₁₂FNO₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
492035 0

Documentation

NSC 721648 - CAS 872726-44-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

NSC 721648 - CAS 872726-44-8 - Calbiochem Certificates of Analysis

TitleLot Number
492035

References

Hivatkozások áttekintése
Aiello, S., et al. 2008. J. Med. Chem. 51, 5135.
Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-January-2009 RFH
Synonyms5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610
DescriptionA cell-permeable benzothiazole compound that exhibits potent in vitro antiproliferative activity against HCC 2998, IGROV1, MCF-7, MDA 468, SR, and T-47D (GI50 <1 nM), while showing much reduced effect against 50 other human tumor cells in a panel screening. Although it is a high affinity AhR ligand (IC50 = 25 nM; Ki = 6.8 nM in a TCDD competitive binding study) and a known CYP1A1 inducer, neither property can fully account for its antitumor activity.
FormWhite crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number872726-44-8
Chemical formulaC₁₅H₁₂FNO₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMF (10 mg/ml) or DMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAiello, S., et al. 2008. J. Med. Chem. 51, 5135.
Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.