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479830 NBI-31772 - CAS 374620-70-9 - Calbiochem

479830
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
374620-70-9C₁₇H₁₁NO₇
Description
Overview

This product has been discontinued.



We are offering NBI 31772 hydrate (Cat. No. N8289) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






A non-peptide ligand that exhibits high-affinity (Ki ~ 1 - 17 nM) towards all six human insulin-like growth factor-I binding proteins (IGFBPs). Displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts; however, it does not interact with the IGF receptors.

Catalogue Number479830
Brand Family Calbiochem®
Synonyms[1-(3ʹ,4ʹ-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]
References
ReferencesChen, C., et al. 2001. J. Med. Chem. 44, 4001.
Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419.
Product Information
CAS number374620-70-9
ATP CompetitiveN
FormGreenish-yellow solid
Hill FormulaC₁₇H₁₁NO₇
Chemical formulaC₁₇H₁₁NO₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHuman insulin-like growth factor-I binding proteins (IGFBPs).
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
479830 0

Documentation

NBI-31772 - CAS 374620-70-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

NBI-31772 - CAS 374620-70-9 - Calbiochem Certificates of Analysis

TitleLot Number
479830

References

Hivatkozások áttekintése
Chen, C., et al. 2001. J. Med. Chem. 44, 4001.
Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms[1-(3ʹ,4ʹ-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]
DescriptionA non-peptide ligand derived from the transformation of L-3,4-dihydroxy-phenylalanine that exhibits high affinity binding to all six human insulin-like growth factor-I binding proteins (IGFGPs) (Ki = 3.36 nM for IGFBP-1, 1.18 nM for IGFBP-2, 5.64 nM for IGFBP-3, 1.54 nM for IGFBP-4, 3.90 nM for IGFBP-5, and 16.6 nM for IGFBP-6). Inhibits insulin-like growth factor (IGF-I) induced cell proliferation in 3T3 fibroblasts through the displacement of IGF-I from the IGF-I:GFBP complex. However, it does not interact with IGF receptors.
FormGreenish-yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number374620-70-9
Chemical formulaC₁₇H₁₁NO₇
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesChen, C., et al. 2001. J. Med. Chem. 44, 4001.
Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419.