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475843 Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem

Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci.

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl

Primary Target: Metalloproteinase (MMP)
475843
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
13614-98-7C₂₃H₂₇N₃O₇ · HCl
Description
Overview

This product has been discontinued.



Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
Catalogue Number475843
Brand Family Calbiochem®
Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
References
ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.
Product Information
CAS number13614-98-7
ATP CompetitiveN
FormDark yellow solid
Hill FormulaC₂₃H₂₇N₃O₇ · HCl
Chemical formulaC₂₃H₂₇N₃O₇ · HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMetalloproteinase (MMP)
Primary Target IC<sub>50</sub>290 µM against MMP-3
Primary Target K<sub>i</sub>13.4 nM against PARP-1
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQI7630500
Safety Information
R PhraseR: 33-36/37/38-63-64

Danger of cumulative effects.
Irritating to eyes, respiratory system and skin.
Possible risk of harm to the unborn child.
May cause harm to breastfed babies.
S PhraseS: 22-45-36

Do not breathe dust.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
475843 0

Documentation

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem Certificates of Analysis

TitleLot Number
475843

References

Hivatkozások áttekintése
Conrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2008 RFH
Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
DescriptionSemi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
FormDark yellow solid
CAS number13614-98-7
RTECSQI7630500
Chemical formulaC₂₃H₂₇N₃O₇ · HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (50 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 6202
ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.