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475841 Miltefosine - CAS 58066-85-6 - Calbiochem

An ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase and displays remarkable antiproliferative effect both in vitro and in vivo.

Miltefosine - CAS 58066-85-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HePC, 1-Hexadecylphosphorylcholine

Primary Target: CTP:phosphocholine cytidyltransferase
475841
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
58066-85-6C₂₁H₄₆NO₄P
Description
OverviewAn ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase and displays remarkable antiproliferative effect both in vitro and in vivo. Also induces apoptosis mediated by cell-permeable ceramides.
Catalogue Number475841
Brand Family Calbiochem®
SynonymsHePC, 1-Hexadecylphosphorylcholine
References
ReferencesWieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
Wieder, T., et al. 1993. Biochem. J. 291, 561.
Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.
Product Information
CAS number58066-85-6
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₂₁H₄₆NO₄P
Chemical formulaC₂₁H₄₆NO₄P
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCTP:phosphocholine cytidyltransferase
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSKH2890000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol or DMSO, aliquot and freeze (-20°C). Stock solutions in ethanol or DMSO are stable for up to 3 months at -20°C. Stock solutions in PBS are stable for up to 24 h at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
475841 0

Documentation

Miltefosine - CAS 58066-85-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Miltefosine - CAS 58066-85-6 - Calbiochem Certificates of Analysis

TitleLot Number
475841

References

Hivatkozások áttekintése
Wieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
Wieder, T., et al. 1993. Biochem. J. 291, 561.
Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2008 RFH
SynonymsHePC, 1-Hexadecylphosphorylcholine
DescriptionAn ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase. Reported to exhibit anti-proliferative and anti-metastatic effects in vitro and in vivo. Also reported to induce apoptosis mediated by cell-permeable ceramides. Shown to have anti-protozoal activity against Leishmania species.
FormCrystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number58066-85-6
RTECSKH2890000
Chemical formulaC₂₁H₄₆NO₄P
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (800 μg/ml), Ethanol (1 mg/ml), or PBS, pH 7.2 (2.5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol or DMSO, aliquot and freeze (-20°C). Stock solutions in ethanol or DMSO are stable for up to 3 months at -20°C. Stock solutions in PBS are stable for up to 24 h at -20°C.
Toxicity Harmful
ReferencesWieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
Wieder, T., et al. 1993. Biochem. J. 291, 561.
Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.