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475816 Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem

Arg-Arg analog of Microcystin-LR that is less toxic. Inhibits protein phosphatase 2A (IC₅₀ = 3.4 nM). Useful for comparative structure and function studies.

Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MCYST-RR

Primary Target: PP2A
475816
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
111755-37-4C₄₉H₇₅N₁₃O₁₂
Description
Overview

This product has been discontinued.




Arg-Arg analog of Microcystin-LR (Cat. No. 475815) that is less toxic. Inhibits protein phosphatase 2A (IC50 = 3.4 nM). Useful for comparative structure and function studies.
Catalogue Number475816
Brand Family Calbiochem®
SynonymsMCYST-RR
References
ReferencesShirai, M., et al. 1991. Appl. Environ. Microbiol. 57, 1241.
Mastsushima, R., et al. 1990. Biochem. Biophys. Res. Commun. 171, 867.
Meriluoto, J.A., et al. 1990. J. Chromatography 509, 309.
Carmichael, W.W. 1989. in Natural Toxins (Ownby, C.L., and O’Dell, G.V., Eds.) p. 3, Pergamon, Elmsford, New York.
Product Information
CAS number111755-37-4
ATP CompetitiveN
DeclarationNot available for sale outside of the United States.
FormOff-white solid
Hill FormulaC₄₉H₇₅N₁₃O₁₂
Chemical formulaC₄₉H₇₅N₁₃O₁₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPP2A
Primary Target IC<sub>50</sub>3.4 nM inhibiting protein phosphatase 2A
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 26/27/28-36/37/38-43

Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by skin contact.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
End use certificateY
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
475816 0

Documentation

Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Microcystin-RR, Microcystis aeruginosa - CAS 111755-37-4 - Calbiochem Certificates of Analysis

TitleLot Number
475816

References

Hivatkozások áttekintése
Shirai, M., et al. 1991. Appl. Environ. Microbiol. 57, 1241.
Mastsushima, R., et al. 1990. Biochem. Biophys. Res. Commun. 171, 867.
Meriluoto, J.A., et al. 1990. J. Chromatography 509, 309.
Carmichael, W.W. 1989. in Natural Toxins (Ownby, C.L., and O’Dell, G.V., Eds.) p. 3, Pergamon, Elmsford, New York.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2008 RFH
SynonymsMCYST-RR
DescriptionArg-Arg analog of Microcystin-LR (Cat. No. 475815) that is less toxic. Inhibitor of protein-phosphatase 2A (IC50 = 3.4 nM). Useful for comparative structure and function studies.
FormOff-white solid
CAS number111755-37-4
Chemical formulaC₄₉H₇₅N₁₃O₁₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (2.5 mg/ml) or Ethanol
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Highly Toxic
ReferencesShirai, M., et al. 1991. Appl. Environ. Microbiol. 57, 1241.
Mastsushima, R., et al. 1990. Biochem. Biophys. Res. Commun. 171, 867.
Meriluoto, J.A., et al. 1990. J. Chromatography 509, 309.
Carmichael, W.W. 1989. in Natural Toxins (Ownby, C.L., and O’Dell, G.V., Eds.) p. 3, Pergamon, Elmsford, New York.