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505207 Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem

Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride

Primary Target: nAChR
505207
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
826-39-1C₁₁H₂₁N•HCl

Products

KatalógusszámCsomagolás Menny./csomag
5.05207.0001 Üvegpalack 10 mg
Description
OverviewA potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders).
Catalogue Number505207
Brand Family Calbiochem®
SynonymsN,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
References
ReferencesHarris, C., et al. 2013. Psychopharmacol. 225, 291.
Lima, H., et al. 2013. Learning & Memory 20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.
Product Information
CAS number826-39-1
FormOff-white solid
Hill FormulaC₁₁H₂₁N•HCl
Chemical formulaC₁₁H₂₁N•HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetnAChR
Primary Target IC<sub>50</sub>640 nM
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 25-36/37/38

Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 22-26-28.1-36/37/39-46-63

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
After contact with skin, wash immediately with plenty of water.
Wear suitable protective clothing, gloves and eye/face protection.
If swallowed, seek medical advice immediately and show this container or label.
In case of accident by inhalation: remove casualty to fresh air and keep at rest.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
5.05207.0001 04055977263435

Documentation

Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Mecamylamine Hydrochloride - CAS 826-39-1 - Calbiochem Certificates of Analysis

TitleLot Number
505207

References

Hivatkozások áttekintése
Harris, C., et al. 2013. Psychopharmacol. 225, 291.
Lima, H., et al. 2013. Learning & Memory 20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
SynonymsN,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
DescriptionA potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette's syndrome, Schizophrenia and various cognitive and mood disorders).
FormOff-white solid
CAS number826-39-1
Chemical formulaC₁₁H₂₁N•HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesHarris, C., et al. 2013. Psychopharmacol. 225, 291.
Lima, H., et al. 2013. Learning & Memory 20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol. 22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother. 10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther. 14, 266.br>J. M. Young et al. 2001. Clin. Ther. 23, 532.