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538768 Lim Kinase Inhibitor II, SR-7826 - Calbiochem

A cell-permeable, highly potent and selective inhibitor of LIM kinase (IC₅₀ = 43 nM).

Lim Kinase Inhibitor II, SR-7826 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2-Hydroxyethyl)-3-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-1-phenylurea, LIMK Inhibitor, SR-7826

538768
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Áttekintés

Replacement Information

Products

KatalógusszámCsomagolás Menny./csomag
5.38768.0001 Üvegpalack 5 mg
Description
OverviewA cell permeable bis-aryl urea that acts as a highly potent and selective LIMK inhibitor (LIM kinase, IC50 = 43 nM for Limk1) with more than 400-fold selectivity against ROCK and JNK kinases. Only displays inhibitory effect on STK16 with ≥80% inhibition at 1 µM in addition to LIMK1 in a 61 kinase panel profiling. Inhibits cofilin phosphorylation in A7r5 (IC50 = 470 nM), PC-3 and CEM-SS T cells (IC50 < 1 µM), shown to inhibit cell invasion by 76% and cell migration by 74% in PC-3 cells at 1 µM. Exhibits desirable pharmacokinetic properties in vitro and in vivo with 36% bioavailability in rats (p.o. at 2mg/kg).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538768
Brand Family Calbiochem®
Synonyms1-(2-Hydroxyethyl)-3-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-1-phenylurea, LIMK Inhibitor, SR-7826
DescriptionLim Kinase Inhibitor II, SR-7826
References
ReferencesYin, Y., et al. 2015. J. Med. Chem. 58, 1846.
Product Information
FormOff-white solid
Hill FormulaC₂₂H₂₁N₅O₂
Chemical formulaC₂₂H₂₁N₅O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetLIMK
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
5.38768.0001 04054839119668

Documentation

Lim Kinase Inhibitor II, SR-7826 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
Yin, Y., et al. 2015. J. Med. Chem. 58, 1846.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-September-2016 JSW
Synonyms1-(2-Hydroxyethyl)-3-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-1-phenylurea, LIMK Inhibitor, SR-7826
DescriptionA cell permeable bis-aryl urea that acts as a highly potent and selective LIMK inhibitor (LIM kinase, IC50 = 43 nM for Limk1) with more than 400-fold selectivity against ROCK and JNK kinases. Only displays inhibitory effect on STK16 with ≥80% inhibition at 1 µM in addition to LIMK1 in a 61 kinase panel profiling. Inhibits cofilin phosphorylation in A7r5 (IC50 = 470 nM), PC-3 and CEM-SS T cells (IC50 < 1 µM), shown to inhibit cell invasion by 76% and cell migration by 74% in PC-3 cells at 1 µM. Exhibits desirable pharmacokinetic properties in vitro and in vivo with 36% bioavailability in rats (p.o. at 2mg/kg).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₂₁N₅O₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C
Toxicity Standard Handling
ReferencesYin, Y., et al. 2015. J. Med. Chem. 58, 1846.