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440209 LY 295427

LY 295427 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3α,4α,5α)-4-(2-Propenyl)cholestan-3-ol

440209
  
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Áttekintés

Replacement Information
Description
Overview

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A novel hypocholesterolemic agent that reduces plasma cholesterol levels in animals by increasing the expression of hepatic low-density lipoprotein (LDL) receptors. However, recent studies have attributed the hypocholesterolemic activity of LY 295427 to its ability to reverse oxysterol-mediated suppression of sterol regulatory element-binding protein (SREBP) processing. Micromolar concentrations of this sterol restored the metabolism of LDL in oxysterol-treated cultured cells and inhibited the stimulation of cholesteryl ester synthesis mediated by oxysterols.
Catalogue Number440209
Brand Family Calbiochem®
Synonyms(3α,4α,5α)-4-(2-Propenyl)cholestan-3-ol
References
ReferencesJanowski, B.A. 2002. Proc. Natl. Acad. Sci. 99, 12675. Janowski, B.A., et al. 2001. J. Biol. Chem. 276, 45408. Lin, H.S., et al. 1999. Steroids 64, 217. Bowling, N., et al. 1996. J. Lipid Res. 37, 2586. Lin, H.S., et al. 1995. J. Med. Chem. 38, 277.
Product Information
FormWhite solid
Hill FormulaC₃₀H₅₂O
Chemical formulaC₃₀H₅₂O
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
440209 0

Documentation

LY 295427 Certificates of Analysis

TitleLot Number
440209

References

Hivatkozások áttekintése
Janowski, B.A. 2002. Proc. Natl. Acad. Sci. 99, 12675. Janowski, B.A., et al. 2001. J. Biol. Chem. 276, 45408. Lin, H.S., et al. 1999. Steroids 64, 217. Bowling, N., et al. 1996. J. Lipid Res. 37, 2586. Lin, H.S., et al. 1995. J. Med. Chem. 38, 277.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-August-2008 RFH
Synonyms(3α,4α,5α)-4-(2-Propenyl)cholestan-3-ol
DescriptionA novel hypocholesterolemic agent that reduces plasma cholesterol levels in animals by increasing the expression of hepatic low-density lipoprotein (LDL) receptors. Also reported to reverse the suppression of sterol regulatory element-binding protein (SREBP) processing mediated by several oxysterols and cholesterol derivative in CHO-7 cells and in human fibroblasts. At micromolar levels, it induces the metabolism of LDL in oxysterol-treated cells and inhibits the stimulation of cholesteryl ester synthesis mediated by oxysterols.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₅₂O
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityEthanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesJanowski, B.A. 2002. Proc. Natl. Acad. Sci. 99, 12675. Janowski, B.A., et al. 2001. J. Biol. Chem. 276, 45408. Lin, H.S., et al. 1999. Steroids 64, 217. Bowling, N., et al. 1996. J. Lipid Res. 37, 2586. Lin, H.S., et al. 1995. J. Med. Chem. 38, 277.