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440165 LXRα/β Agonist - CAS 264206-85-1 - Calbiochem

LXRα/β Agonist - CAS 264206-85-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-((4-Methoxyphenyl)amino)-4-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione

Primary Target: A potent and specific liver X receptor (LXR) dual agonist
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
264206-85-1C₂₄H₂₀N₂O₃
Description
Overview

This product has been discontinued.



A cell-permeable maleimide analog that acts as a potent and specific liver X receptor (LXR) dual agonist (EC50 = 50 nM and 40 nM for the recruitment of SRC1 to LXRα and LXRβ, respectively). Displays >50-fold selectivity for LXR over a panel of nuclear receptors, including FXR, PPARα/γ/δ, PXR, AR, ERα/β, GR, and PR. Upregulates ABCA1-dependent transcriptional activity (EC50 = 80 nM) and inhibits LPS-stimulated secretion of the proinflammatory cytokine, IL-6, in THP-1 cells.
Catalogue Number440165
Brand Family Calbiochem®
Synonyms3-((4-Methoxyphenyl)amino)-4-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione
References
ReferencesJaye, M.C., et al. 2005. J. Med. Chem. 48, 5419.
Product Information
CAS number264206-85-1
ATP CompetitiveN
FormOrange solid
Hill FormulaC₂₄H₂₀N₂O₃
Chemical formulaC₂₄H₂₀N₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA potent and specific liver X receptor (LXR) dual agonist
Primary Target IC<sub>50</sub>EC50 = 50 nM and 40 nM for the recruitment of SRC1 to LXRα and LXRβ, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
440165 0

Documentation

LXRα/β Agonist - CAS 264206-85-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

LXRα/β Agonist - CAS 264206-85-1 - Calbiochem Certificates of Analysis

TitleLot Number
440165

References

Hivatkozások áttekintése
Jaye, M.C., et al. 2005. J. Med. Chem. 48, 5419.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-((4-Methoxyphenyl)amino)-4-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione
DescriptionA cell-permeable maleimide analog that acts as a potent and specific liver X receptor (LXR) dual agonist (EC50 = 50 nM and 40 nM for the recruitment of SRC1 to LXRα and LXRβ, respectively). Displays >50-fold selectivity for LXR over a panel of nuclear receptors, including FXR, PPARα/γ/δ, PXR, AR, ERα/β, GR, and PR. Upregulates ABCA1-dependent transcriptional activity (EC50 = 80 nM) and inhibits LPS-stimulated secretion of the proinflammatory cytokine, IL-6, in THP-1 cells.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number264206-85-1
Chemical formulaC₂₄H₂₀N₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml) or Methanol (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Toxicity Standard Handling
ReferencesJaye, M.C., et al. 2005. J. Med. Chem. 48, 5419.