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530656 LTA4 Epoxide Hydrolase Inhibitor, ARM1 - Calbiochem

A cell-permeable, selective inhibitor of the epoxide hydrolase activity of leukotriene A4 hydrolase (Ki = 2.3 µM).

LTA4 Epoxide Hydrolase Inhibitor, ARM1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-Benzylphenyl)-thiazol-2-amine, Leukotriene A4 Epoxide Hydrolase Inhibitor, LTA₄ Hydrolase Inhibitorq, LTA4H Inhibitor

Primary Target: LTA4
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₁₆H₁₄N₂S
Description
Overview

This product has been discontinued.



A cell-permeable benzylphenyl-thiazolamine compound that acts as a selective inhibitor against the epoxide hydrolase activity of leukotriene A4 hydrolase (LTA4H; Ki = 2.3 µM) and inhibits A23187- (Cat. Nos. 100105 & 100106) induced leukotriene B4 (LTB4) synthesis in primary human polymorphonuclear neutrophil (PMN) cultures (IC50 = 0.5 µM). Does not affect LTA4H aminopeptidase activity toward the cleavage of Pro-Gly-pro even at a high concentratin of 100 µM. Binds to the hydrophobic pocket that accommodates LTA4 ω-end, which is distant from the aminopeptidase active site.
Catalogue Number530656
Brand Family Calbiochem®
Synonyms4-(4-Benzylphenyl)-thiazol-2-amine, Leukotriene A4 Epoxide Hydrolase Inhibitor, LTA₄ Hydrolase Inhibitorq, LTA4H Inhibitor
References
ReferencesStsiapanava, A., et al. 2014. Proc. Natl. Acad. Sci. USA 111, 4227.
Product Information
FormLight beige powder
Hill FormulaC₁₆H₁₄N₂S
Chemical formulaC₁₆H₁₄N₂S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetLTA4
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
530656 0

Documentation

LTA4 Epoxide Hydrolase Inhibitor, ARM1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
Stsiapanava, A., et al. 2014. Proc. Natl. Acad. Sci. USA 111, 4227.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-June-2014 JSW
Synonyms4-(4-Benzylphenyl)-thiazol-2-amine, Leukotriene A4 Epoxide Hydrolase Inhibitor, LTA₄ Hydrolase Inhibitorq, LTA4H Inhibitor
DescriptionA cell-permeable benzylphenyl-thiazolamine compound that selectively inhibits against the leukotriene (LT) A4 epoxide hydrolase activity of LTA4H by occupying the same hydrophobic tunnel (Ki = 2.3 µM) targeted by LTA4 ω-end, displaying much reduced potency against LTA4H aminopeptidase activity (% inhibition/[ARM1] = 0/100 µM & 35/1 mM; Substrate = 800 µM Pro-Gly-Pro) coordinated by E296 and the catalytic site Zn2+ at the adjacent hydrophilic peptide substrate-binding cavity. Shown to inhibit A23187- (Cat. Nos. 100105 & 100106) induced LTB4 production in primary human polymorphonuclear neutrophil (PMN) cultures (IC50 = 0.5 µM; ARM1 added 10 min prior to 5 min stimulation by 2.5 µM A23187). Another LTA4H inhibitor SC 57461A (CAS 423169-68-0), in comparison, inhibits both the LTA4-to-LTB4 conversion as well as the chemotactic tripeptide Pro-Gly-Pro degradation activity of LTA4H.
FormLight beige powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₆H₁₄N₂S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesStsiapanava, A., et al. 2014. Proc. Natl. Acad. Sci. USA 111, 4227.