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438210 LSF Inhibitor, FQI1 - Calbiochem

438210
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Áttekintés

Kulcsspecifikációk táblázata

Empirical Formula
C₁₈H₁₇NO₄

Products

KatalógusszámCsomagolás Menny./csomag
438210-10MG Üvegpalack 10 mg
Description
OverviewA cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
Catalogue Number438210
Brand Family Calbiochem®
Synonyms(±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
Application Data
References
ReferencesGrant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.
Product Information
FormWhite powder
Hill FormulaC₁₈H₁₇NO₄
Chemical formulaC₁₈H₁₇NO₄
Quality LevelMQ100
Biological Information
Purity>92% by HPLC
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
438210-10MG 04055977187052