489479 Sigma-AldrichLSD1 Inhibitor IV, RN-1, 2HCl - Calbiochem
LSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM).
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Synonyms: LSD Inhibitor IV, KDM1 Inhibitor IV, Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV
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Áttekintés
Kulcsspecifikációk táblázata
| Empirical Formula |
|---|
| C₂₃H₂₉N₃O₂ • 2HCl |
Products
| Katalógusszám | Csomagolás | Menny./csomag | |
|---|---|---|---|
| 489479-10MG | Üvegpalack | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable tranylcypromine (parnate; Cat. No. 616431) analog that acts as a potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM in a HRP-coupled assay using H3K4Me2 peptide substrate). Forms a covalent adduct with flavin adenine dinucleotide (FAD). Shown to cross the blood brain barrier. Exhibits moderate selectivity over amine oxidases MAO-A and MAO-B (IC50 = 0.51 and 2.785 µM, respectively). Displays desirable pharmacokinetic properties (brain/plasma exposure ratio of 88.9), and impairs long-term memory without affecting short-term memory in mice (10 mg/kg, i.p.). |
| Catalogue Number | 489479 |
| Brand Family | Calbiochem® |
| Synonyms | LSD Inhibitor IV, KDM1 Inhibitor IV, Histone Lysine Demethylase Inhibitor VI, MOA Inhibitor III, 2-(1R,2S)-2-(4-(Benzyloxy)phenyl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone, HCl, BHC110 Inhibitor IV |
| References | |
|---|---|
| References | Neelamegam, R., et al. 2011. ACS Chem. Neurosci. 3, 120. |
| Product Information | |
|---|---|
| Form | Yellow solid |
| Hill Formula | C₂₃H₂₉N₃O₂ • 2HCl |
| Chemical formula | C₂₃H₂₉N₃O₂ • 2HCl |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ200 |
| Applications | |
|---|---|
| Application | LSD1 Inhibitor IV, RN-1, HCl, is a cell-permeable, potent, irreversible inhibitor of lysine specific demethylase 1 (LSD1; IC50 = 70 nM). |
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Katalógusszám | GTIN |
| 489479-10MG | 04055977273403 |