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407272 Integrin αvβ3 Antagonist, P11 - Calbiochem

The Integrin αvβ3 Antagonist, P11 controls the biological activity of Integrin αvβ3.

Integrin αvβ3 Antagonist, P11 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HSDVHK-NH2, HSDVHK

407272
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₃₀H₅₁N₁₂O₉₃· 3TFA

Products

KatalógusszámCsomagolás Menny./csomag
407272-5MG Üvegpalack 5 mg
Description
OverviewA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
Catalogue Number407272
Brand Family Calbiochem®
SynonymsHSDVHK-NH2, HSDVHK
References
ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
Choi, Y., et al. 2010. Proteomics 10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
Product Information
FormWhite solid
FormulationSupplied as a trifluoracetate salt.
Hill FormulaC₃₀H₅₁N₁₂O₉₃· 3TFA
Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
407272-5MG 04055977188769

Documentation

Integrin αvβ3 Antagonist, P11 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Integrin αvβ3 Antagonist, P11 - Calbiochem Certificates of Analysis

TitleLot Number
407272

References

Hivatkozások áttekintése
Bang, J., et al. 2011. Mol Cell Proteomics 10, M110.
Choi, Y., et al. 2010. Proteomics 10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-jul-2012
SynonymsHSDVHK-NH2, HSDVHK
DescriptionA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
FormWhite solid
FormulationSupplied as a trifluoracetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
Choi, Y., et al. 2010. Proteomics 10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.