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580550 InSolution™ Tautomycetin, S. griseochromogenes

InSolution™ Tautomycetin, S. griseochromogenes MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TMC, TC

580550
  
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Áttekintés

Replacement Information
Description
OverviewA cell-permeable Tautomycin (Cat. No. 580551) structural analog that acts as a selective PP1 inhibitor with ~38-fold greater potency compared to PP2A (IC50 = 1.6 nM for PP1 and 62 nM for PP2A). Inhibits LDP-1, PP2B, and PP5 only at much higher concentrations (IC50 ≥ 1 µM). Shown to completely inhibit intracellular PP1 activity at 5 µM without affecting PP2A in COS-7 cells. TMC is superior to Cyclosporin A (Cat. No. 239835) as a T cell immunosuppressor both in vitro and in vivo.
Catalogue Number580550
Brand Family Calbiochem®
SynonymsTMC, TC
References
ReferencesMitsuhashi, S., et al. 2003. J. Biol. Chem. 278, 82. Shim, J.H., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 10617. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
Product Information
CAS number119757-73-2
FormLiquid
FormulationA 1 mM (50 µg/82 µl) solution in DMSO.
Hill FormulaC₃₃H₅₀O₁₀
Chemical formulaC₃₃H₅₀O₁₀
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPP1
Primary Target IC<sub>50</sub>1.6 nM
Secondary targetPP2A (IC₅₀ = 62 nM)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSWX0900000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
580550 0

Documentation

InSolution™ Tautomycetin, S. griseochromogenes Certificates of Analysis

TitleLot Number
580550

References

Hivatkozások áttekintése
Mitsuhashi, S., et al. 2003. J. Biol. Chem. 278, 82. Shim, J.H., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 10617. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
SynonymsTMC, TC
DescriptionA cell-permeable Tautomycin (Cat. No. 580551) structural analog that acts as a selective PP1 inhibitor with ~38-fold greater potency compared to PP2A (IC50 = 1.6 nM for PP1 and 62 nM for PP2A). Inhibits LDP-1, PP2B, and PP5 only at much higher concentrations (IC50 ≥ 1 µM). Shown to completely inhibit intracellular PP1 activity at 5 µM without affecting PP2A in COS-7 cells. TMC is superior to Cyclosporin A (Cat. No. 239835) as a T cell immunosuppressor both in vitro and in vivo.
FormLiquid
FormulationA 1 mM (50 µg/82 µl) solution in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number119757-73-2
RTECSWX0900000
Chemical formulaC₃₃H₅₀O₁₀
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Flammable
ReferencesMitsuhashi, S., et al. 2003. J. Biol. Chem. 278, 82. Shim, J.H., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 10617. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.