Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

569396 InSolution™ Staurosporine, Streptomyces sp.

InSolution™ Staurosporine, Streptomyces sp. CAS 62996-74-1, is provided as a 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO

InSolution™ Staurosporine, Streptomyces sp. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MLCK Inhibitor I, PKA Inhibitor II

Primary Target: PKA
569396
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
62996-74-1C₂₈H₂₆N₄O₃

Products

KatalógusszámCsomagolás Menny./csomag
569396-100UG Muanyagampulla 100 μg
Description
Catalogue Number569396
Brand Family Calbiochem®
SynonymsMLCK Inhibitor I, PKA Inhibitor II
References
ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
Bruno, S., et al. 1992. Cancer Res. 52, 470.
Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
Vitale, M.L., et al. 1992. Neuroscience 51, 463.
Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol. 28, 102.
Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
Product Information
CAS number62996-74-1
ATP CompetitiveY
FormLiquid
FormulationA 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO.
Hill FormulaC₂₈H₂₆N₄O₃
Chemical formulaC₂₈H₂₆N₄O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™ Staurosporine, Streptomyces sp. CAS 62996-74-1, is provided as a 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO
Biological Information
Primary TargetPKA
Primary Target IC<sub>50</sub>7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
569396-100UG 07790788051693

Documentation

InSolution™ Staurosporine, Streptomyces sp. MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ Staurosporine, Streptomyces sp. Certificates of Analysis

TitleLot Number
569396

References

Hivatkozások áttekintése
Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
Bruno, S., et al. 1992. Cancer Res. 52, 470.
Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
Vitale, M.L., et al. 1992. Neuroscience 51, 463.
Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol. 28, 102.
Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

Citations

Titulus
  • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
  • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-July-2008 JSW
    SynonymsMLCK Inhibitor I, PKA Inhibitor II
    DescriptionA potent, cell-permeable broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.
    FormLiquid
    FormulationA 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    CAS number62996-74-1
    Chemical formulaC₂₈H₂₆N₄O₃
    Structure formulaStructure formula
    Purity≥97% by HPLC
    Storage Protect from light
    ≤ -70°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-70°C).
    Toxicity Irritant
    ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
    Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
    Bruno, S., et al. 1992. Cancer Res. 52, 470.
    Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
    Vitale, M.L., et al. 1992. Neuroscience 51, 463.
    Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol. 28, 102.
    Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
    Citation
  • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
  • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
    		•