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508227 InSolution™ Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

InSolution™ Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL® InSolution

Primary Target: microtubules
508227
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
33069-62-4C₄₇H₅₁NO₁₄

Products

KatalógusszámCsomagolás Menny./csomag
5.08227.0001 Üvegpalack 10 mg
Description
Catalogue Number508227
Brand Family Calbiochem®
SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL® InSolution
References
ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
Product Information
CAS number33069-62-4
FormLiquid
FormulationA 25 mM (10 mg/468 µL) sterile-filtered solution of Paclitaxel, Taxus sp. (Cat. No. 580555) in DMSO.
Hill FormulaC₄₇H₅₁NO₁₄
Chemical formulaC₄₇H₅₁NO₁₄
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetmicrotubules
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
5.08227.0001 04055977261783

Documentation

InSolution™ Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
SynonymsBaccatin III N-benzyl-β-phenylisoserine Ester, TAXOL® InSolution
DescriptionAntitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
FormLiquid
FormulationA 25 mM (10 mg/468 µL) sterile-filtered solution of Paclitaxel, Taxus sp. (Cat. No. 580555) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number33069-62-4
Chemical formulaC₄₇H₅₁NO₁₄
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Toxicity Standard Handling
ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.