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444968 InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

InSolution™ MEK1/2 Inhibitor III, PD0325901, CAS 391210-10-9, is a 50 mM solution of MEK1/2 Inhibitor III, PD0325901 in DMSO. A cell-permeable, potent, non-competitive MEK/MAPKK/MKK inhibitor.

InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901

444968
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
391210-10-9C₁₆H₁₄F₃IN₂O₄

Products

KatalógusszámCsomagolás Menny./csomag
444968-5MG Üvegpalack 5 mg
Description
OverviewA cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
Catalogue Number444968
Brand Family Calbiochem®
SynonymsPD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
References
ReferencesBarrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
Silva, J., et al. 2008. PLoS Biol. 6, 2237.
Ying, Q.L., et al. 2008. Nature 453, 519.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Solit, D.B., et al. 2006. Nature 439, 358.
Product Information
CAS number391210-10-9
FormLiquid
FormulationA 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
Hill FormulaC₁₆H₁₄F₃IN₂O₄
Chemical formulaC₁₆H₁₄F₃IN₂O₄
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™ MEK1/2 Inhibitor III, PD0325901, CAS 391210-10-9, is a 50 mM solution of MEK1/2 Inhibitor III, PD0325901 in DMSO. A cell-permeable, potent, non-competitive MEK/MAPKK/MKK inhibitor.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
444968-5MG 04055977204544

Documentation

InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem Certificates of Analysis

TitleLot Number
444968

References

Hivatkozások áttekintése
Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
Silva, J., et al. 2008. PLoS Biol. 6, 2237.
Ying, Q.L., et al. 2008. Nature 453, 519.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Solit, D.B., et al. 2006. Nature 439, 358.

Brochure

Title
New Products: Volume 3, 2012
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2012 JSW
SynonymsPD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
DescriptionA cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
FormLiquid
FormulationA 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number391210-10-9
Chemical formulaC₁₆H₁₄F₃IN₂O₄
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Regulatory Review
ReferencesBarrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
Silva, J., et al. 2008. PLoS Biol. 6, 2237.
Ying, Q.L., et al. 2008. Nature 453, 519.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Solit, D.B., et al. 2006. Nature 439, 358.