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504042 InSolution™ Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem

504042
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
25316-40-9C₂₇H₂₉NO₁₁ · HCl
Description
Catalogue Number504042
Brand Family Calbiochem®
SynonymsAdriamycin, HCl, 14-Hydroxydaunomycin, HCl
References
ReferencesA'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
Theyer, G., et al. 1993. J. Urol. 150, 1544.
Tritton, T.R., and Yee, G. 1982. Science 217, 248.
Product Information
CAS number25316-40-9
FormLiquid
FormulationA 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.
Hill FormulaC₂₇H₂₉NO₁₁ · HCl
Chemical formulaC₂₇H₂₉NO₁₁ · HCl
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
504042 0

Documentation

InSolution™ Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
A'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
Theyer, G., et al. 1993. J. Urol. 150, 1544.
Tritton, T.R., and Yee, G. 1982. Science 217, 248.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2014 JSW
SynonymsAdriamycin, HCl, 14-Hydroxydaunomycin, HCl
DescriptionAn anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.
FormLiquid
FormulationA 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number25316-40-9
Chemical formulaC₂₇H₂₉NO₁₁ · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.
Toxicity Standard Handling
ReferencesA'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
Theyer, G., et al. 1993. J. Urol. 150, 1544.
Tritton, T.R., and Yee, G. 1982. Science 217, 248.