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401020 Imiquimod - CAS 99011-02-6 - Calbiochem

An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties.

Imiquimod - CAS 99011-02-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine

Primary Target: TLR7 (toll-like receptor 7)
401020
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
99011-02-6C₁₄H₁₆N₄

Products

KatalógusszámCsomagolás Menny./csomag
401020-250MG Muanyagampulla 250 mg
Description
OverviewAn imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.
Catalogue Number401020
Brand Family Calbiochem®
Synonyms1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
References
ReferencesMajewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.
Product Information
CAS number99011-02-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₁₆N₄
Chemical formulaC₁₄H₁₆N₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTLR7 (toll-like receptor 7)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 25-36/37/38

Toxic if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
401020-250MG 04055977189414

Documentation

Imiquimod - CAS 99011-02-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Imiquimod - CAS 99011-02-6 - Calbiochem Certificates of Analysis

TitleLot Number
401020

References

Hivatkozások áttekintése
Majewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-May-2009 JSW
Synonyms1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
DescriptionAn imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number99011-02-6
Chemical formulaC₁₄H₁₆N₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (3 mg/ml); warming to 60°C is required for complete solubilization.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.
Toxicity Toxic
ReferencesMajewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.