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401474 IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

IKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).

IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan

Primary Target: IKKα and β kinase activity
401474
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
524-12-9C₁₆H₁₀O₇
Description
OverviewThe naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.
Catalogue Number401474
Brand Family Calbiochem®
SynonymsWedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
References
ReferencesKobori, M., et al. 2004. Cell Death Differ. 11, 123.
Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
Mors, W.B., et al. 1989. Toxicon 27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.
Product Information
CAS number524-12-9
ATP CompetitiveN
FormYellowish-green, crystalline powder
Hill FormulaC₁₆H₁₀O₇
Chemical formulaC₁₆H₁₀O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationIKK Inhibitor II, Wedelolactone, CAS 524-12-9, is a cell-permeable, selective, irreversible inhibitor of IKKα and β kinase activity (IC50 = 10 µM).
Biological Information
Primary TargetIKKα and β kinase activity
Primary Target IC<sub>50</sub>< 10 µM against IKKα and β kinase activity
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
401474 0

Documentation

IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem Certificates of Analysis

TitleLot Number
401474

References

Hivatkozások áttekintése
Kobori, M., et al. 2004. Cell Death Differ. 11, 123.
Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
Mors, W.B., et al. 1989. Toxicon 27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-October-2009 RFH
SynonymsWedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
DescriptionCell-permeable. The naturally-occuring active ingredient from the herbal medicine, Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.
FormYellowish-green, crystalline powder
Intert gas (Yes/No) Packaged under inert gas
CAS number524-12-9
Chemical formulaC₁₆H₁₀O₇
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Methanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKobori, M., et al. 2004. Cell Death Differ. 11, 123.
Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
Mors, W.B., et al. 1989. Toxicon 27, 1003.
Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.