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401011 Hypothemycin - CAS 76958-67-3 - Calbiochem

A cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol analog that inhibits several kinases via an initial affinity binding to the ATP pocket.

Hypothemycin - CAS 76958-67-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 354462

401011
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
76958-67-3C₁₉H₂₂O₈
Description
OverviewA cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCμ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.
Catalogue Number401011
Brand Family Calbiochem®
SynonymsNSC 354462
References
ReferencesSchirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
Solit, D.B., et al. 2006. Nature 439, 358.
Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.
Product Information
CAS number76958-67-3
FormLyophilized solid
Hill FormulaC₁₉H₂₂O₈
Chemical formulaC₁₉H₂₂O₈
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
401011 0

Documentation

Hypothemycin - CAS 76958-67-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Hypothemycin - CAS 76958-67-3 - Calbiochem Certificates of Analysis

TitleLot Number
401011

References

Hivatkozások áttekintése
Schirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
Solit, D.B., et al. 2006. Nature 439, 358.
Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2010 RFH
SynonymsNSC 354462
DescriptionA cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCµ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.
FormLyophilized solid
Intert gas (Yes/No) Packaged under inert gas
CAS number76958-67-3
Chemical formulaC₁₉H₂₂O₈
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSchirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
Solit, D.B., et al. 2006. Nature 439, 358.
Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.