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401006 Hypoestoxide, Hypoestes rosea - Calbiochem

A naturally occurring, cell-permeable diterpene with anti-inflammatory properties.

Hypoestoxide, Hypoestes rosea - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: IKB Kinase
401006
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₂₂H₃₂O₅
Description
OverviewA naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells, thereby preventing NF-κB activation. Also inhibits the production of nitric oxide by IL-1β or IL-17 stimulated normal human chondrocytes. Reported to neither affect the synthesis of prostaglandin nor inhibit the activities of JNK and p38MAPK.
Catalogue Number401006
Brand Family Calbiochem®
References
ReferencesPulai, J.I., et al. 2005. J. Immunol. 174, 5781.
Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₃₂O₅
Chemical formulaC₂₂H₃₂O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIKB Kinase
Primary Target IC<sub>50</sub>24 µM against IκB kinase
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
401006 0

Documentation

Hypoestoxide, Hypoestes rosea - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Hypoestoxide, Hypoestes rosea - Calbiochem Certificates of Analysis

TitleLot Number
401006

References

Hivatkozások áttekintése
Pulai, J.I., et al. 2005. J. Immunol. 174, 5781.
Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2008 RFH
DescriptionA naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells thereby prevents NF-κB activation. Also inhibits the production of nitric oxide in IL-1β or IL-17 stimulated normal human chondrocytes. Does not inhibit the activities of JNK and p38MAPK. Reported to be effective against murine blood and liver stages of malarial parasites. Inhibits VEGF-induced cell proliferation in vitro (IC50 = 28.6 µM) and bFGF-induced angiogenesis in the chick chorioallantoic membrane (IC50 = 10 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₃₂O₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (3 mg/ml) (slight warming may be required) or Ethanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.
Toxicity Harmful
ReferencesPulai, J.I., et al. 2005. J. Immunol. 174, 5781.
Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.