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CC1025 Human Integrin αVβ5, Triton X-100 Formulation

Human Integrin αVβ5, Triton X-100 Formulation MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Positive Control UniProt Number: P06756 Entrez Gene Number: NM_002210.2
CC1025
50 µg  
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Áttekintés

Replacement Information
Description
Catalogue NumberCC1025
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionHuman Integrin αVβ5, Triton X-100 Formulation
OverviewIntegrin alphaV beta5 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alphaV beta5 integrin. Two bands are identified with silver stain, corresponding to alphaV (145kDa) and beta5 (90kDa) subunits under nonreducing conditions. Product was tested and found negative for HIV, HBsAg, syphilis, and hepatitis. Integrin alphaV beta5 interacts with vitronectin in ELISA.
References
Product Information
PresentationPurified protein in 20 mM Tris-HCl, pH 7.5, 150 mM NaCl, 2 mM MgCl, 0.2% Triton X-100, with no preservatives.
Quality LevelMQ100
Applications
Key Applications
  • Positive Control
Application NotesElectrophoresis, Immunoblotting, and Ligand Binding studies.
Biological Information
Purity>95% by SDS-PAGE (silver stain) Two main protein bands corresponding to aV (145 kD) and β5 (90 kD) subunits are seen in silver stained

gel under non-reduced conditions.
Entrez Gene Number
Entrez Gene SummaryITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
Gene Symbol
  • ITGAV
  • DKFZp686A08142
  • MSK8
  • CD51
  • VNRA
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
CC1025 04053252405457

Documentation

Human Integrin αVβ5, Triton X-100 Formulation MSDS

Title

Safety Data Sheet (SDS) 

Human Integrin αVβ5, Triton X-100 Formulation Certificates of Analysis

TitleLot Number
HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION - 2101952 2101952
HUMAN INTEGRIN alphaV beta5 - 3192042 3192042
HUMAN INTEGRIN alphaV beta5 - 3715132 3715132
HUMAN INTEGRIN alphaV beta5 -2607290 2607290
HUMAN INTEGRIN alphaV beta5 -2846398 2846398
HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION 2984207
HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION 3057116
HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION - 2013399 2013399
HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION - 3978937 3978937

Data Sheet

Title
HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION