Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

373400 Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503

373400
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
64048-12-0C₂₄H₁₆N₄S

Products

KatalógusszámCsomagolás Menny./csomag
373400-5MG Muanyagampulla 5 mg
Description
OverviewA cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
Catalogue Number373400
Brand Family Calbiochem®
Synonyms4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
References
ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
Product Information
CAS number64048-12-0
FormYellow solid
Hill FormulaC₂₄H₁₆N₄S
Chemical formulaC₂₄H₁₆N₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
373400-5MG 04055977191110

Documentation

Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem Certificates of Analysis

TitleLot Number
373400

References

Hivatkozások áttekintése
Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
DescriptionA cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number64048-12-0
Chemical formulaC₂₄H₁₆N₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.