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373225 Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V

Primary Target: ubiquitination of p53 in vitro
373225
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
414905-09-2C₁₀H₈F₆N₂O₃S

Products

KatalógusszámCsomagolás Menny./csomag
373225-5MG Muanyagampulla 5 mg
Description
Overview

This product has been discontinued.



A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 > 100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
Catalogue Number373225
Brand Family Calbiochem®
SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
References
ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
Product Information
CAS number414905-09-2
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₀H₈F₆N₂O₃S
Chemical formulaC₁₀H₈F₆N₂O₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetubiquitination of p53 in vitro
Primary Target IC<sub>50</sub>12.7 µM inhibiting ubiquitination of p53 in vitro using Ub-Ubc as the donor substrate
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
373225-5MG 04055977190977

Documentation

Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem Certificates of Analysis

TitleLot Number
373225

References

Hivatkozások áttekintése
Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-July-2014 JSW
SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
DescriptionA cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 >100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number414905-09-2
Chemical formulaC₁₀H₈F₆N₂O₃S
Structure formulaStructure formula
Purity≥95% by NMR
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.