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361558 GSK-3 Inhibitor XV - Calbiochem

GSK-3 Inhibitor XV, is a cell-permeable, reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively).

GSK-3 Inhibitor XV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: GSK-3
361558
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₂₅H₁₄BrN₃O₆Ru
Description
Overview

This product has been discontinued.



The racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
Catalogue Number361558
Brand Family Calbiochem®
References
ReferencesAtilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.
Product Information
ATP CompetitiveY
DeclarationSold for research purposes only, pursuant to an agreement with University of Pennsylvania. Sold under license of U.S. Patent 7,488,817.
FormPurple solid
Hill FormulaC₂₅H₁₄BrN₃O₆Ru
Chemical formulaC₂₅H₁₄BrN₃O₆Ru
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationGSK-3 Inhibitor XV, is a cell-permeable, reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively).
Biological Information
Primary TargetGSK-3
Primary Target IC<sub>50</sub>0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
361558 0

Documentation

GSK-3 Inhibitor XV - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

GSK-3 Inhibitor XV - Calbiochem Certificates of Analysis

TitleLot Number
361558

References

Hivatkozások áttekintése
Atilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-February-2008 JSW
DescriptionThe racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
FormPurple solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅H₁₄BrN₃O₆Ru
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (6 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAtilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.