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371706 GPR40 Agonist - CAS 885101-89-3 - Calbiochem

The GPR40 Agonist, also referenced under CAS 885101-89-3, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Cell Signaling applications.

GPR40 Agonist - CAS 885101-89-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I

371706
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
885101-89-3C₂₂H₂₁NO₃

Products

KatalógusszámCsomagolás Menny./csomag
371706-10MG Muanyagampulla 10 mg
Description
OverviewA cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GPR40 (EC50 ~50 nM) with much reduced activity towards family members GPR120 (EC50 ~3.5 µM), GPR41/GPR43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
Catalogue Number371706
Brand Family Calbiochem®
Synonyms3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
References
ReferencesMcKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
Product Information
CAS number885101-89-3
FormLight yellow solid
Hill FormulaC₂₂H₂₁NO₃
Chemical formulaC₂₂H₂₁NO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
371706-10MG 04055977213898

Documentation

GPR40 Agonist - CAS 885101-89-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

GPR40 Agonist - CAS 885101-89-3 - Calbiochem Certificates of Analysis

TitleLot Number
371706

References

Hivatkozások áttekintése
McKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-January-2011 RFH
Synonyms3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
DescriptionA cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40 (EC50 ~50 nM) with much reduced activity towards family members GRP120 (EC50 ~3.5 µM), GRP41/GRP43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number885101-89-3
Chemical formulaC₂₂H₂₁NO₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (40 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMcKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.