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364200 GM 1489

GM 1489 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide

Primary Target: MMP-1
364200
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
170905-75-6C₂₇H₃₃N₃O₄
Description
Overview

This product has been discontinued.



A potent broad-range inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro (Ki = 0.2 nM for MMP-1; Ki = 500 nM for MMP-2; Ki = 20 µM for MMP-3; Ki = 100 nM for MMP-8; and Ki = 100 nM for MMP-9). Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
Catalogue Number364200
Brand Family Calbiochem®
SynonymsN-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide
References
ReferencesSato, N., et al. 2003. J. Natl. Cancer Inst. 95, 327.
Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.
Product Information
CAS number170905-75-6
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₇H₃₃N₃O₄
Chemical formulaC₂₇H₃₃N₃O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-1
Primary Target K<sub>i</sub>0.2 nM for MMP-1; 500 nM for MMP-2; 20 µM for MMP-3; 100 nM for MMP-8; 100 nM for MMP-9
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
364200 0

Documentation

GM 1489 MSDS

Title

Safety Data Sheet (SDS) 

GM 1489 Certificates of Analysis

TitleLot Number
364200

References

Hivatkozások áttekintése
Sato, N., et al. 2003. J. Natl. Cancer Inst. 95, 327.
Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-July-2008 RFH
SynonymsN-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide
DescriptionA potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.2 nM for interstitial collagenase (MMP-1); Ki = 500 nM for gelatinase A (MMP-2); Ki = 20 µM for stromelysin (MMP-3); Ki = 100 nM for neutrophil collagenase (MMP-8); Ki = 100 nM for gelatinase B (MMP-9)]. Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
FormOff-white solid
CAS number170905-75-6
Chemical formulaC₂₇H₃₃N₃O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSato, N., et al. 2003. J. Natl. Cancer Inst. 95, 327.
Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.