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371818 G-Protein βγ Binding Peptide, mSIRK - Calbiochem

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide

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G-Protein βγ Binding Peptide, mSIRK - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: mSIRK, myr-SIRKALNILGYPDYD-OH

Primary Target: N-myristoylated G-protein βγ selective binding
371818
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Áttekintés

Kulcsspecifikációk táblázata

Empirical Formula
C₉₃H₁₅₀N₂₀O₂₅

Products

KatalógusszámCsomagolás Menny./csomag
371818-1MG Üvegpalack 1 mg
Hozzáadás a Kedvencekhez
371818-5MG Üvegpalack 5 mg
Hozzáadás a Kedvencekhez
Description
OverviewA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
Catalogue Number371818
Brand Family Calbiochem®
SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
References
ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
Scott, J.K., et al. 2001. EMBO J. 20, 767.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₉₃H₁₅₀N₂₀O₂₅
Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary TargetN-myristoylated G-protein βγ selective binding
Primary Target IC<sub>50</sub>EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
371818-1MG 04055977213423
371818-5MG 04055977213430