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344280 Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: FST, Phosphotrienin

Primary Target: PP2a
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
87860-39-7C₁₉H₂₆O₉PNa
Description
Overview

This product has been discontinued.



An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC50 = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.
Catalogue Number344280
Brand Family Calbiochem®
SynonymsFST, Phosphotrienin
References
ReferencesCheng, A., et al. 1998. Cancer Res. 58, 3611.
Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.
Product Information
CAS number87860-39-7
ATP CompetitiveN
FormColorless solid
Hill FormulaC₁₉H₂₆O₉PNa
Chemical formulaC₁₉H₂₆O₉PNa
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPP2a
Primary Target IC<sub>50</sub>3.2 nM, 131 µM, against protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1), respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUQ0600000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
344280 0

Documentation

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem Certificates of Analysis

TitleLot Number
344280

References

Hivatkozások áttekintése
Cheng, A., et al. 1998. Cancer Res. 58, 3611.
Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.

Brochure

Title
Protein Phosphatases Technical Bulletin

Citations

Titulus
  • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision26-June-2008 RFH
    SynonymsFST, Phosphotrienin
    DescriptionAntitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Also inhibits protein phosphatase 1 (PP1) at higher concentrations (IC50 = 131 µM), but has no effect on protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.
    FormColorless solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number87860-39-7
    RTECSUQ0600000
    Chemical formulaC₁₉H₂₆O₉PNa
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityEthanol (10 mg/ml), Methanol (10 mg/ml), or H₂O (50 mg/ml)
    Storage Protect from light
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    Toxicity Standard Handling
    ReferencesCheng, A., et al. 1998. Cancer Res. 58, 3611.
    Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
    Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.
    Citation
  • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.
    		•