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344960 FUT-175 - CAS 82956-11-4 - Calbiochem

A synthetic broad-specificity serine protease inhibitor.

FUT-175 - CAS 82956-11-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Futhan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate

Primary Target: Granzyme A
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
82956-11-4C₂₁H₂₅N₅O₈S₂
Description
Overview

This product has been discontinued.



A synthetic broad-specificity serine protease inhibitor. Potently inhibits both coagulation and complement proteinases as well as Granzyme A. Also effective toward Hageman factor and Factor Xa at submicromolar concentrations.
Catalogue Number344960
Brand Family Calbiochem®
SynonymsFuthan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate
References
ReferencesKam, C.M., et al. 2000. Biochim. Biophys. Acta 1477, 307.
Pfeifer, P.H., et al. 1999. Clin. Chem. 45, 1190.
Blum, M.G., et al. 1998. Xenotransplantation 5, 35.
Uchiba, M., et al. 1994. Thromb. Res. 74, 155.
Inagi, R., et al. 1991. Immunol. Lett. 27, 49.
Poe, M., et al. 1991. Arch. Biochem. Biophys. 284, 215.
Issekutz, A.C., et al. 1990. Int. J. Immunopharmacol. 12, 1.
Ikari, N., et al. 1983. Immunology 49, 685.
Product Information
CAS number82956-11-4
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₁H₂₅N₅O₈S₂
Chemical formulaC₂₁H₂₅N₅O₈S₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetGranzyme A
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDG2736000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-80°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions in H₂O are stable for up to 6 months at -80°C or up to 4 weeks at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
344960 0

Documentation

FUT-175 - CAS 82956-11-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

FUT-175 - CAS 82956-11-4 - Calbiochem Certificates of Analysis

TitleLot Number
344960

References

Hivatkozások áttekintése
Kam, C.M., et al. 2000. Biochim. Biophys. Acta 1477, 307.
Pfeifer, P.H., et al. 1999. Clin. Chem. 45, 1190.
Blum, M.G., et al. 1998. Xenotransplantation 5, 35.
Uchiba, M., et al. 1994. Thromb. Res. 74, 155.
Inagi, R., et al. 1991. Immunol. Lett. 27, 49.
Poe, M., et al. 1991. Arch. Biochem. Biophys. 284, 215.
Issekutz, A.C., et al. 1990. Int. J. Immunopharmacol. 12, 1.
Ikari, N., et al. 1983. Immunology 49, 685.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-May-2008 RFH
SynonymsFuthan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate
DescriptionA synthetic broad-specificity serine protease inhibitor. Potently inhibits both coagulation and complement proteinases (C3a, C4a, and C5a) as well as Granzyme A. Inhibits Factor VIIa-mediated, Factor Xa generation (IC50 = 100 nM). Also effective toward Hageman factor at submicromolar concentrations.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Recommended reaction conditions50 µg/ml
CAS number82956-11-4
RTECSDG2736000
Chemical formulaC₂₁H₂₅N₅O₈S₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (5 mg/ml). The use of PBS or other phosphate-containing buffers should be avoided as it may reduce solubility.
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-80°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions in H₂O are stable for up to 6 months at -80°C or up to 4 weeks at 4°C.
Toxicity Standard Handling
Merck USA index14, 6350
ReferencesKam, C.M., et al. 2000. Biochim. Biophys. Acta 1477, 307.
Pfeifer, P.H., et al. 1999. Clin. Chem. 45, 1190.
Blum, M.G., et al. 1998. Xenotransplantation 5, 35.
Uchiba, M., et al. 1994. Thromb. Res. 74, 155.
Inagi, R., et al. 1991. Immunol. Lett. 27, 49.
Poe, M., et al. 1991. Arch. Biochem. Biophys. 284, 215.
Issekutz, A.C., et al. 1990. Int. J. Immunopharmacol. 12, 1.
Ikari, N., et al. 1983. Immunology 49, 685.