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344597 FTY720

FTY720 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl

344597
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
162359-56-0C₁₉H₃₃NO₂ • HCl

Products

KatalógusszámCsomagolás Menny./csomag
344597-10MG Üvegpalack 10 mg
Description
Overview

A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Catalogue Number344597
Brand Family Calbiochem®
Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
References
ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
Mandala, S., et al. 2002. Science 296, 346.
Chiba, K., et al. 1998. J. Immunol. 160, 5037.
Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
Product Information
CAS number162359-56-0
FormSolid
Hill FormulaC₁₉H₃₃NO₂ • HCl
Chemical formulaC₁₉H₃₃NO₂ • HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
344597-10MG 04055977214796

Documentation

FTY720 Certificates of Analysis

TitleLot Number
344597

References

Hivatkozások áttekintése
Brinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
Mandala, S., et al. 2002. Science 296, 346.
Chiba, K., et al. 1998. J. Immunol. 160, 5037.
Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2008 RFH
Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
DescriptionA cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number162359-56-0
Chemical formulaC₁₉H₃₃NO₂ • HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
Mandala, S., et al. 2002. Science 296, 346.
Chiba, K., et al. 1998. J. Immunol. 160, 5037.
Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.