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324673 EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem

The EGFR/ErbB-2 Inhibitor, also referenced under CAS 179248-61-4, controls the biological activity of EGFR/ErbB-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline

Primary Target: EGFR
324673
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
179248-61-4C₂₃H₂₁N₃O₃
Description
Overview

This product has been discontinued.



A cell-permeable 4-

anilino quinazoline compound that acts a potent, reversible, and ATP-competitive inhibitors of EGFR and c-erbB2 (IC50 = 20 nM and 79 nM, respectively), members of the type I growth factor receptor family that is involved in breast cancer development and progression. Shown to effectively inhibit the proliferation (IC50 = ~ 1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
Catalogue Number324673
Brand Family Calbiochem®
Synonyms4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline
References
ReferencesCockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
Product Information
CAS number179248-61-4
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₃H₂₁N₃O₃
Chemical formulaC₂₃H₂₁N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>20 nM and 79 nM, against EGFR and c-erbB2, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
324673 0

Documentation

EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

EGFR/ErbB-2 Inhibitor - CAS 179248-61-4 - Calbiochem Certificates of Analysis

TitleLot Number
324673

References

Hivatkozások áttekintése
Cockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-September-2007 JSW
Synonyms4557W, 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline
DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of EGFR (IC50 = 20 nM) and c-erbB2 (IC50 = 79 nM), members of the type I growth factor receptor family implicated in the development and progression of various forms of cancer, including breast and small lung cell carcinoma. Shown to effectively inhibit the proliferation (IC50 ~1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number179248-61-4
Chemical formulaC₂₃H₂₁N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml) or Methanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesCockerill, S., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1401.