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324414 Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem

The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide

324414
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
1128165-88-7C₂₅H₃₆N₄O

Products

KatalógusszámCsomagolás Menny./csomag
324414-10MG Üvegpalack 10 mg
Description
OverviewA cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.
Catalogue Number324414
Brand Family Calbiochem®
Synonyms2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
References
ReferencesChircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.
Product Information
CAS number1128165-88-7
FormYellow solid
Hill FormulaC₂₅H₃₆N₄O
Chemical formulaC₂₅H₃₆N₄O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
324414-10MG 04055977197204

Documentation

Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem Certificates of Analysis

TitleLot Number
324414

References

Hivatkozások áttekintése
Chircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
Synonyms2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
DescriptionA cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1128165-88-7
Chemical formulaC₂₅H₃₆N₄O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml; clear, yellow solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.