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324378 Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem

Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid

Primary Target: Glutamate kainate receptor
324378
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
14277-97-5C₁₅H₂₁NO₆
Description
Overview

This product has been discontinued.



A heat-stable neurotoxin. Glutamate kainate receptor agonist that shows higher affinity for the kainate receptor than any other known kainic acid analog. Causes excessive excitation of neurons resulting in the depletion of energy stores, cellular edema, and death. Inhibits adenylate cyclase activity in neuronal membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
Catalogue Number324378
Brand Family Calbiochem®
Synonyms25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
References
ReferencesAlfonso, M., et al. 1994. Neurochem. Int. 24, 267.
Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
Wright, P., et al. 1989. Can. J. Chem. 67, 481.
Product Information
CAS number14277-97-5
ATP CompetitiveN
FormWhite to off-white crystaline solid
Hill FormulaC₁₅H₂₁NO₆
Chemical formulaC₁₅H₂₁NO₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGlutamate kainate receptor
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUX9665100
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
324378 0

Documentation

Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem Certificates of Analysis

TitleLot Number
324378

References

Hivatkozások áttekintése
Alfonso, M., et al. 1994. Neurochem. Int. 24, 267.
Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
Wright, P., et al. 1989. Can. J. Chem. 67, 481.

Brochure

Title
Excitotoxic Glutamate Analogs Technical Bulletin
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-May-2008 RFH
Synonyms25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
DescriptionGlutamate kainate excitatory amino acid agonist with the highest affinity for the kainate receptor of all known kainic acid analogs. It has been used to purify the kainate receptor by affinity chromatography. Its binding to the receptor causes continuous stimulation of nerve cells leading to depletion of energy, cellular edema, and death. Its neurological effect resembles anterograde memory loss associated with Alzheimer's disease. Inhibits adenylate cyclase activity in brain membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
FormWhite to off-white crystaline solid
CAS number14277-97-5
RTECSUX9665100
Chemical formulaC₁₅H₂₁NO₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (8 mg/ml) or Methanol (0.6 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
Toxicity Harmful
Merck USA index14, 3417
ReferencesAlfonso, M., et al. 1994. Neurochem. Int. 24, 267.
Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
Wright, P., et al. 1989. Can. J. Chem. 67, 481.