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292505 Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem

An esterase-sensitive and cell permeable, O²-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol).

Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
292505
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
213768-16-2C₇H₁₅N₃O₄

Products

KatalógusszámCsomagolás Menny./csomag
292505-1MG Muanyagampulla 1 mg
Description
OverviewAn esterase-sensitive and cell permeable, O2-acetoxymethylated diazeniumdiolate that acts as an intracellular nitric oxide (NO) donor (1.83 mol of NO/mol). Shown to induce apoptosis and to act as an antiproliferative agent in NO-sensitive human leukemia HL-60 (IC50 = 8.3 µM) and U937 (IC50 = 53 µM) cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation in bovine aortic endothelial cells. Exhibits enhanced stability in physiological buffers. May also be useful for temporal and spatial controlled NO availability.
Catalogue Number292505
Brand Family Calbiochem®
References
ReferencesKotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.
Product Information
CAS number213768-16-2
ATP CompetitiveN
FormYellow liquid
Hill FormulaC₇H₁₅N₃O₄
Chemical formulaC₇H₁₅N₃O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIntracellular nitric oxide (NO) donor
Primary Target IC<sub>50</sub>8.3 µM, 53 µM, acting as an antiproliferative agent in NO-sensitive human leukemia HL-60 and U937 cell lines, respectively
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
292505-1MG 04055977197945

Documentation

Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Diethylamine NONOate/AM - CAS 213768-16-2 - Calbiochem Certificates of Analysis

TitleLot Number
292505

References

Hivatkozások áttekintése
Kotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2011 RFH
DescriptionA cell-permeable O2-acetoxymethylated diazeniumdiolate that donates nitric oxide (NO) following the action of intracellular esterases (1.83 mol of NO/mol). Shown to induce apoptosis and act as an antiproliferative agent in NO-sensitive human leukemia HL-60 (IC50 = 8.3 µM) and U937 (IC50 = 53 µM) cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation (~5 µM) in bovine aortic endothelial cells. Useful for temporal and spatial controlled NO availability.
FormYellow liquid
Intert gas (Yes/No) Packaged under inert gas
CAS number213768-16-2
Chemical formulaC₇H₁₅N₃O₄
Structure formulaStructure formula
Purity≥95% by NMR
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C. Add to aqueous medium just prior to use.
Toxicity Standard Handling
ReferencesKotamraju, S., et al. 2001. J. Biol. Chem. 276, 17316.
Saavedra, J.E., et al. 2000. J. Med. Chem. 43, 261.